Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-03-21
2006-03-21
Richter, Johann (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S207000
Reexamination Certificate
active
07015234
ABSTRACT:
Compounds of the general formula (I)are described wherein R1and R2, which may be the same or different, is each a hydrogen atom or a CF3, CF2H or CFH2group, provided that when one of R1and R2is a hydrogen atom, then the other is a CF3, CF2H or CFH2group, and the salts, solvates or hydrates thereof. Compounds of the invention are potent MMP inhibitors which advantageously do not cause tendonitis in a relevant animal model. Compounds of the invention may be expected to be of use in medicine, especially where the avoidance of side effects, such as joint pain, is desired.
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Barta, T.E., et al., “Synthesis and activity of selective MMP inhibitors with an aryl backbone,”Bioorganic&Medicinal Chem. Letts.,2000, 10, 2815-2817.
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Dyke Hazel Joan
Watson Robert John
Celltech R & D Limited
Nwaonicha Chukwuma
Richter Johann
Woodcock & Washburn LLP
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