Organic compounds -- part of the class 532-570 series – Organic compounds – Hydroxamic acids – chalcogen analogs or salts thereof
Patent
1994-04-20
1995-08-15
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Hydroxamic acids, chalcogen analogs or salts thereof
562623, C07C25906
Patent
active
054421101
ABSTRACT:
##STR1## A compound represented by general formula (I), a pharmaceutical composition containing same, a process for the production thereof, and an intermediate therefor. In formula (I) R.sup.1 represents lower alkyl which may be substituted by a substituent selected from the group consisting of mercapto, lower alkylthio, arylthio and lower acylthio; R.sup.2, R.sup.3 and R.sup.4 may be the same or different from one another and each represents lower alkyl; X represents oxygen or sulfur; and Y represents a single bond or lower alkylene. The compound (I) has a matrix metalloprotease inhibitory activity and is useful for preventing and treating diseases caused by the progress of connective tissue breakage.
REFERENCES:
Matsuda, et al, Bunseki Kagaku (1986) 35(3) 151-156 *Abstract*.
Akamatsu Seijiro
Isomura Yasuo
Kudou Masafumi
Suga Akira
Yoden Toru
Conrad, III Joseph M.
Dees Jos,e G.
Yamanouchi Pharmaceutical Co. Ltd.
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