Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1993-04-16
1998-05-26
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560312, 562448, 562561, 562621, 562623, 534 10, 534 14, 534 15, 534 16, 424 153, 424 165, 424 169, 424 934, C07C22900, C07C23900
Patent
active
057568251
ABSTRACT:
The present disclosure details the preparation of hydroxamic-acid based bifunctional chelators and their use in conjugating metal ions to proteins and nucleic acids for tumor or tissue imaging or therapy purposes. Some preferred aspects of the disclosure involve the preparation of trisuccin, acid, which is a hydroxamic acid/succinate based structure that is particularly useful for binding radionuclides such as .sup.99m Tc, .sup.186 Re and .sup.67 Cu.
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Buchsbaum Donald J.
Kazaeli Mohammad Bagher
Safavy Ahmad
Kelley Lara C.
Kight John
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