Hydroxamate derivatives of selected nonsteroidal antiinflammator

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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562442, 562443, 562444, 562448, 562449, 562450, 562428, 562434, 562435, 562437, 564102, 564162, 564163, 564164, 564165, 564166, 564167, 564168, 564169, 564170, 564172, 564176, 564180, 548195, 548337, 548557, 548558, 560 9, 560 10, 560 11, 560 12, 560 13, 560 16, 560 20, 560 21, 560 22, 560 23, 560 24, 560 28, 560 29, 560 30, 560 31, 560 32, 560 33, 514255, 514352, 514371, 514398, 514426, 514447, 514472, 514480, 514561, 514562, 514563, 514608, 514617, 514619, 514620, 514621, 514622, 544336, 546309, A61K 313

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051128683

ABSTRACT:
The present invention is novel selected hydroxamic acid derivatives of acyl residues of selected NSAIDS, i.e. having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by the inhibition and methods for treating these conditions in mammals, including humans suffering therefor.

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patent: 4092430 (1978-05-01), Sallmann et al.
patent: 4173577 (1979-11-01), Sallmann et al.
Arzneimittel Forschung Drug Research, vol. 30(II), No. 8a, Aug. 1980, pp. 1314-1325 (1980).
Poster Session--ACS Meeting New Orleans Sep. 1987.
J. Med. Chem., 1987, 30, 574-580.
J. Med. Chem., 1987, 30, 2121-2126.
Wolf, E., and Kohl, H., Ann. Chem. Liegigs, 1975, 1245-1251.

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