Hydroxamate derivatives of selected nonsteroidal antiinflammator

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544143, 544373, 548495, 5142332, 514253, C07D20928, C07D41302, C07D40302, A61K 31405

Patent

active

049435876

ABSTRACT:
The present invention is novel selected hydroxamic acid derivatives of acyl residues of selected NSAIDS, i.e. having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by the inhibition and methods for treating these conditions in mammals, including humans suffering therefor.

REFERENCES:
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patent: 4092430 (1978-05-01), Sallmann et al.
patent: 4173577 (1979-11-01), Sallmann et al.
Poster Session--ACS Meeting New Orleans 9/87.
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J. Med. Chem., 1987, 30, 2121-2126.
Wolf, E., and Kohl, H. Ann. Chem. Liegigs, 1975, 1245-1251.

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