Hydrosoluble rifamycins and process for their preparation

Details Hydrosoluble rifamycins and process for their preparation Hydrosoluble rifamycins and process for their preparation

1977-07-01

1979-04-17

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, C07D49808

Patent

active

041500237

ABSTRACT:
This application relates to hydrosoluble rifamycins consisting of a molecular associations between a rifamycin derivative and an alkaline salt of an organic acid in a molar ratio 1 rifamycin to 0.5 to 5 alkali metal salt. These hydrosoluble rifamycins are obtained by solubilization of the respective rifamycin derivatives with the selected solubilizing agent, in a suitable organic solvent and they are isolated through dilution with a hydrocarbon, after a vacuum concentration by filtration and drying, or through evaporation. These products realize a prolonged gutliver recycling and a lower toxicity, against the liver cell.

REFERENCES:
patent: 3342810 (1967-09-01), Maggi et al.
patent: 3862934 (1975-01-01), Cricchio et al.
patent: 3933800 (1976-01-01), Cricchio et al.
patent: 4005076 (1977-01-01), Cricchio et al.
Burger, "Medicinal Chemistry" 2nd Ed. (1960), (Interscience) pp. 46-71.

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