Hydrosoluble extracts of mycobacteria, their preparation and use

Details Hydrosoluble extracts of mycobacteria, their preparation and use Hydrosoluble extracts of mycobacteria, their preparation and use

1973-06-19

1976-05-11

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3902

Patent

active

039564819

ABSTRACT:
Hydrosoluble extracts of mycobacteria suitable as immunological adjuvants are prepared. These extracts have a molecular weight between 3,500 and 30,000 and adjuvant, non-arthrogen properties. The delipidated bacterial residues of mycobacteria are subjected to a mild extraction, then the so-obtained substance is isolated and purified by physicochemical methods, or the delipidated bacterial residues of mycobacteria are treated by means of pyridine, optionally in the presence of acetic anhydride, then the obtained products are treated with ethanol or water, and the hydrosoluble substances are isolated and purified by physicochemical methods.

REFERENCES:
patent: 3529057 (1970-09-01), Tsuchiya et al.
Engibarov--Chem. Abst., Vol. 68 (1968), p. 85115t.
Birnbaum et al.--Chem. Abst., Vol. 71 (1969), 109957j.
Motomiya et al.--Chem. Abst., Vol. 70 (1969), p. 65420b.
Roszman et al.--Chem. Abst., Vol. 68 (1968), p. 76570k.
Goeing et al.--Chem. Abst., Vol. 66 (1967), p. 74398v.
Adam et al., Chemical Abstracts 77: 17903j (1972).
Chedid et al., Chemical Abstracts 77: 17904k (1972).

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