Hydroquinone derivatives and preparation thereof

Details Hydroquinone derivatives and preparation thereof Hydroquinone derivatives and preparation thereof

1979-07-30

1981-05-26

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfur containing

568608, 568609, C07C14708, C07C 4320, C07C 43205

Patent

active

042700035

ABSTRACT:
The novel hydroquinone derivatives of the formula (I) are useful intermediates for the preparation of coenzyme Q, vitamin K and the polyprenyltrimethylquinones: ##STR1## wherein R.sup.1 is lower alkyl, lower alkoxy lower alkyl or methoxyethoxymethyl, R.sup.2 and R.sup.3 are each methyl or methoxy, or R.sup.2 and R.sup.3, taken together with the carbon atoms from which they depend, define a benzene ring, and R.sup.4 is a substituted or unsubstituted aromatic hydrocarbon. The compounds (I) are readily prepared either by reacting a Grignard reagent of the formula (II) with a halosulfone (III) in the presence of a copper compound, or by reacting a copper derivative (II') of the Grignard reagent (II) with a halo-sulfone (III), as follows: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined as above, and X is a halogen atom or a tosyl group.

REFERENCES:
patent: 4089873 (1978-05-01), Rapoport et al.

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