Hydropyridine derivatives

Details Hydropyridine derivatives Hydropyridine derivatives

1988-08-03

1989-05-23

Brust, Joseph P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514538, 514567, 546205, 546206, 546290, 546291, 546298, 546309, 546310, 546316, 546322, 560 38, 560 39, 560 43, 562443, 562444, 562449, 562452, A61K 31195, A61K 31165, A61K 31215, C07C10130

Patent

active

048331694

ABSTRACT:
Hydropyridine derivatives of the formula ##STR1## in which R.sub.1 represents carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl, R.sub.2 represents hydrogen, an optionally etherified or acylated hydroxy group or an optionally acylated amino group, and R.sub.3 represents a radical of the formula R-- (Ia), R--alk.sub.1 -- (Ib) or R'.dbd.alk.sub.2 -- (Ic) in which R represents a benzocycloalkenyl radical having a total of from 8 to 12 ring carbon atoms which is bonded via a saturated carbon atom and which is unsubstituted or is mono- or poly-substituted in the benzo moiety by hydroxy, lower alkoxy, lower alkanoyloxy, halogen, lower alkyl and/or by trifluoromethyl, and/or subsituted in the .alpha.-position by lower alkyl, and R' represents a benzocycloalkylidene radical having a total of from 8 to 12 ring carbon atoms which is unsubstituted or is mono- or poly-substituted in the benzo moiety by hydroxy, lower alkoxy, lower alkanoyloxy, halogen, lower alkyl and/or by trifluoromethyl, and alk.sub.1 represents lower alkylene or lower alkylidene and alk.sub.2 represents lower alkyl-.omega.-ylidene, wherein the dotted line is intended to show that there may be a single bond or especially a double bond, and 3-aminopropionic acid compounds of the formula R.sub.3 --NH--CH.sub.2 CH.sub.2 --R.sub.1 (IVc) in which R.sub.1 and R.sub.3 have the meanings given above, and their pharmaceutically acceptable salts, have nootropic properties and can be used as nootropic active ingredients in medicaments. They are manufactured by methods known per se.

REFERENCES:
patent: 3408391 (1968-10-01), Skorcz
patent: 3513244 (1970-05-01), Gittos et al.
patent: 3534055 (1970-10-01), Gittos et al.
patent: 3622614 (1971-11-01), Jenny et al.
patent: 3629463 (1974-12-01), Gittos et al.
patent: 4238488 (1980-12-01), Howe et al.
patent: 4383999 (1983-05-01), Bondinell et al.
patent: 4410519 (1983-10-01), Seiler et al.
patent: 4446141 (1984-05-01), Nakamizo et al.
patent: 4629727 (1986-12-01), Kozlik et al.
Abstract of France [Published 2-25-77] 2,319,330.
Abstract of Netherland [Published 2-'-65] 6,408,887.
Dictionary of Organic Compounds, 5th ed., vol. 1, (1982), p. 550, N.Y.-London-Toronto, Chapman & Hall.
J. Med. Chem., vol. 25, pp. 1358-1363, (1982); Kanao et al.
J. Pharm. Sci., vol. 67, pp. 880-882, (1978); Dren et al.

Affiliated with

Also associated with

Rating

Hydropyridine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydropyridine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydropyridine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1731095