Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2005-05-24
2005-05-24
Spector, Lorraine (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S350000, C530S399000, C530S359000, C436S071000, C514S012200, C514S506000, C514S762000
Reexamination Certificate
active
06897297
ABSTRACT:
Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
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Baker Darren P.
Galdes Alphonse
Garber Ellen A.
Pepinsky R. Blake
Petter Russell C.
Biogen Idec Inc.
Curis, Inc.
O'Hara Eileen B
Ropes & Gray LLP
Spector Lorraine
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