Hydrophobic vitamin B.sub.12 derivatives

Details Hydrophobic vitamin B.sub.12 derivatives Hydrophobic vitamin B.sub.12 derivatives

1994-05-25

1996-04-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

540474, C07H 2300, A61K 3168

Patent

active

055104797

ABSTRACT:
A novel hydrophobic vitamin B.sub.12 derivative represented by the formula: ##STR1## wherein R represents an alkyl group having 2 to 17 carbon atoms, and X represents a cyano group, a hydroxyl group, an alkyl group or a 5'-deoxyadenosyl group. Since the derivative is hydrophobic, it can be taken up by an organism by thermodynamic diffusion, a passive transport, without an active transport.

REFERENCES:
patent: 2967860 (1961-01-01), Perlman et al.
patent: 2984661 (1961-05-01), Nomine et al.
patent: 5405839 (1995-04-01), Toraya et al.
Toraya, T. et al. "Preparation, Properties and Biological Activities of Succinyl Derivatives of Vitamin B12," Chemical Abstracts 83(11): p. 638, col. 1, 1975.

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