Hydrophobic peptide esters and amides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435 681, 435 692, 514 2, 514 19, 530333, 530343, 530344, 530300, C12P 2100

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053044746

ABSTRACT:
Esters or amides of a peptide, preferably a dipeptide, consisting essentially of natural or synthetic L-amino acids with hydrophobic side chains were found to have specific cellular toxicities. Preferable amino acids of the peptide are leucine, phenylalanine valine, isoleucine, alanine, proline, glycine or aspartic acid beta methyl ester. Preferable dipeptides are L leucyl L-leucine, L-leucyl L-phenylalanine, L-valyl L-phenylalanine, L-leucyl L-isoleucine, L-phenylalanyl L-phenylalanine, L-valyl L-leucine, L-leucyl L-alanine, L-valyl L-valine, L-phenylalanyl L leucine, L prolyl L-leucine, L-leucyl L-valine, L-phenylalanyl L-valine, L glycyl L-leucine, L-leucyl L-glycine, glycyl L-phenylalanine and L-aspartyl beta methyl ester L-phenylalanine. Most preferable dipeptides are L-leucyl L-leucine, L-leucyl L-phenylalanine, L-valyl L-phenylalanine, L-phenylalanyl L-leucine, L-leucyl L-isoleucine L-phenylalanyl L-phenylalanine and L-valyl L-leucine.

REFERENCES:
patent: 4555502 (1985-11-01), Patchett et al.
patent: 4585757 (1986-04-01), Pang et al.
patent: 4616012 (1986-10-01), Neustadt et al.
patent: 4752602 (1988-06-01), Lipsky et al.
McGuire et al., Chemical Abstracts, vol. 25, 1992, #250866x.
Thiele et al., Proc. Natl. Acad. Sci.; vol. 82, 1985, pp. 2468-2472.
Goldman, Jul. 1973, Dipeptide Hydrolysis Within Intact Lysosomes In Vitro, vol. 33, No. 2, pp. 208-212.
Reeves, Sep. 1979, Accumulation of Amino Acids by Lysosomes Incubated with Amino Acid Methyl Esters*, The Journal of Biological Chemistry, vol. 254, No. 18, pp. 8914-8921.
Thiele et al., Nov. 1983, Phenotype of the Accessory Cell Necessary for Mitogen-Stimulated T and B Cell Responses in Human Peripheral Blood: Delineation By Its Sensitivity to The Lysosomotropic Agent, L-Leucine Methyl Ester, The Journal of Immunology, vol. 131, No. 5., pp. 2282-2290.
Verhoef et al., Jul. 1983, Inhibition of Human Natural Killer Activity by Lysosomotropic Agents, The Journal of Immunology, vol. 131, No. 1, pp. 125-131.
Shau et al., Feb. 1985, Depletion of NK Cells With The Lysosomotropic Agent L-Leucine Methyl Ester And The In Vitro Generation of NK Activity From NK Precursor Cells, The Journal Of Immunology, vol. 134, No. 2, pp. 1136-1141.
Trinchieri et al., 1978, Anti-Viral Activity Induced By Culturing Lymphocytes With Tumor-Derived Or Virus-Transformed Cells, J Exp Med, vol. 147, No. 1, pp. 1314-1333.
Charley et al., Nov. 1986, Prevention of Lethal Murine Graft Versus Host Disease by Treatment of Donor Cells with L-Leucyl-L-Leucine Methyl Ester, J Clin Invest, vol. 78, pp. 1415-1420.
Thiele et al., Jan. 1987, Lethal Graft-VS-Host Diesease Across Major Histocompatibility Barriers: Requirement for Leucyl-Leucine Methyl Ester Sensitive Cytotoxic T Cells, The Journal of Immunology, vol. 138, No. 1, pp. 51-57.
Gidlund et al., Jun. 1978, Enhanced NK Cell Activity In Mice Injected With Interferon And Interferon Inducers, Nature, vol. 273, pp. 759-761.
Lopez et al., Nov. 1979, Association Between Pre-Transplant Natural Kill and Graft-Versus-Host Disease After Stem-Cell Transplantation, The Lancet, pp. 1103-1106.
Seeley et al, Sep. 1979, Studies on Cytotoxicity Generated In Human Mixed Lymphocyte Cultures, The Journal of Immunology, vol. 123, No. 3, pp. 1303-1311.
Roder et al., Dec. 1979, Target-Effector Interaction In The Natural Killer Cell System, The Journal of Immunology, vol. 123, No. 6, pp. 2785-2790.
Kendall et al., Dec. 1980, The Dual Effect of Prostaglandin (PGE.sub.2) and Ethanol on the Natural Killer Cytolytic Process: Effector Activation and NK-Cell-Target Cell Conjugate Lytic Inhibition, The Journal of Immunology, vol. 125, No. 6, pp. 2770-2777.
Lopez et al., Nov. 1980, Natural Killer Cells in Bone Marrow Transplantation, The Lancet, p. 1025.
Breard et al., Apr. 1980, A Monoclonal Antibody Reactive With Human Peripheral Blood Monocytes, The Journal of Immunology, vol. 124, No. 4, pp. 1943-1948.
Zarling et al., Dec. 1981, Phenotypes of Human Natural Killer Cell Populations Detected With Monoclonal Antibodies, The Journal of Immunology, vol. 127, No. 6, pp. 2575-2580.
Ortaldo et al., Dec. 1981, Determination of Surface Antigens on Highly Purified Human NK Cells By Flow Cytometry With Monoclonal Antibodies, The Journal of Immunology, vol. 127, No. 6, pp. 2401-2409.
Timonen et al., Mar. 1981, Characteristics of Human Large Granular Lymphocytes and Relationship to Natural Killer and K Cells, J Exp Med, vol. 153, pp. 569-582.
Reeves et al., Jul. 1981, Intracellular Disruption of Rat Heart Lysosomes by Leucine Methyl Ester: Effects on Protein Degradation, Proc Natl Acad Sci USA, vol. 78, No. 7, pp. 4426-4429.
Herberman et al., 1981, Natural Killer Cells: Their Role in Defenses Against Diseases, Science, vol. 214, pp. 24-30.
Dokhelar et al., Jan. 1981, Natural Killer Cell Activity in Human Bone Marrow Recipients, Transplantation, vol. 31, No. 1, pp. 61-65.
Grimm et al., Jun. 1982, Lymphokine-Activated Killer Cell Phenomenon, Journal of Experimental Medicine, vol. 155, pp. 1823-1841.
Warner et al., Nov. 1982, Effects of a Cloned Cell Line With NK Activity on Bone Marrow Transplants, Tumor Development and Metastasis In Vivo, Nature, vol. 300, pp. 31-34.
Hiserodt et al., Nov. 1982, Differential Effects of Various Pharmacologic Agents on the cytolytic Reaction Mechanism of the Human Natural Killer Lymphocyte: Further Resolution of Programming for Lysis and KCIL into Discrete Stages, The Journal of Immunology, vol. 129, No. 5, pp. 2266-2270.
Quan et al., Apr. 1982, Studies on the Mechanism of NK Cell Lysis, The Journal of Immunology, vol. 128, No. 4, pp. 1786-1791.
Seaman et al., Apr. 1982, Suppression of Natural Killing in Vitro by Monocytes and Polymorphonuclear Leukocytes, The Journal of Clinical investigation, vol. 69, pp. 876-888.
Dempsey et al., Dec. 1982, The Differential Effects of Human Leukocytic Pyrogen/Lymphocyte-Activating Factor, T Cell Growth Factor, and Interferon on Human Natural Killer Activity, The Journal of Immunology, vol. 129, No. 6, pp. 2504-2510.
Koren et al., 1982, Modulation of Human NK Cells by Interferon and Prostaglandin E.sub.2, Molecular Immunology, vol. 19, No. 10, pp. 1341-1346.
Katz et al., Jul. 1982, Mechanisms of Human Cell-Mediated Cytotoxicity, The Journal of Immunology, vol. 129, No. 1, pp. 287-296.
Hiserodt et al., Oct. 1982, Characterization of the Cytolytic Reaction Mechanism of the Human Natural Killer (NK) Lymphocyte: Resolution into Binding, Programming, and Killer Cell-Independent Steps, The Journal of Immunology, vol. 129, No. 4, pp. 1782-1787.
Bonavida et al., 1983, Molecular Interactions in T-Cell-Mediated Cytotoxicity, Immunological Rev, vol. 72, pp. 119-141.
Podack et al., Mar. 1983, Assembly of Two Types of Tubules With Putative Cytolytic Function by Cloned Natural Killer Cells, Nature, vol. 302, pp. 442-445.
Dennert et al., May 1983, Cytolysis By H-2-Specific T Killer Cells, J Exp Med, vol. 157, pp. 1483-1495.
Burns et al., Dec. 1983, Human Natural Killer Cells, Activated Lymphocyte Killer Cells, and Monocytes Possess Similar Cytotoxic Mechanisms, Proc Natl Acas Sci USA, vol. 80, pp. 7606-7610.
Hattori et al., Aug. 1983, Inhibition of Human Natural Killer (NK) Activity and Antibody Dependent Cellular Cytotoxicity (ADCC) By Lipomodulin, A Phospholipase Inhibitory Protein, The Journal of Immunology, vol. 131, No. 2, pp. 662-665.
Perussia et al. May 1983, Human Natural Killer Cells Analyzed by B73.1, A Monoclonal Antibody Blocking Fc Receptor Functions, The Journal of Immunology, vol. 130, No. 5, pp. 2133-2141.
Seaman, Dec. 1983, Human Natural Killer Cell Activity is Reversibly Inhibited By Antagonists of Lipoxygenation, The Journal of Immunology, vol. 131, No. 6, pp. 2953-2957.
Domzig et al., Apr. 1983, Interleukin 2 Dependence of Human Natural Killer (NK) Cell Activity, The Journal of Immunology, vol. 130, No. 4, pp. 1970-1973.
Komiyama et al., 1984, Childhood Acute Lymphoblastic Leukemia with Natural Killer Activity, Cancer, vol. 54, p. 1547.
Kleinerman et al., Jul. 1984, Tumoricidal Activity of Human Monocytes: Evidence for Cytolytic Function Distinct from that of NK Cells, The Journal o

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