Hydrophobic multicomponent heparin conjugates, a preparing...

Details Hydrophobic multicomponent heparin conjugates, a preparing... Hydrophobic multicomponent heparin conjugates, a preparing...

2006-10-31

2006-10-31

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C106S162200, C536S021000

Reexamination Certificate

active

07129224

ABSTRACT:
The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the present invention provides hydrophobic heparin conjugates that are prepared by covalently binding a polymer to heparin and a hydrophobic agent to the polymer. The hydrophobic heparin conjugates of the present invention maintain a good antithrombogenic effect and are insoluble in water due to their hydrophobicity, so they can be effectively used as coating agents for modifying the surfaces of medical devices.

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