Hydrophobic cis-platinum complexes efficiently incorporated into

Details Hydrophobic cis-platinum complexes efficiently incorporated into Hydrophobic cis-platinum complexes efficiently incorporated into

1991-05-31

1993-02-16

Shaver, Paul F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 3722

Patent

active

051869403

ABSTRACT:
The present invention involves the synthesis and use of new platinum compounds. These new platinum compounds are easy to encapsulate in liposomes at high efficiencies. They are further characterized as platinum (II) four coordinate complex having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are carboxylato monoanions bearing a hydrophobic radical function or a single carboxylato dianion bearing a hydrophobic radical function and R.sub.3 is a vicinal diaminoalkane or vicinal diaminocycloalkane. The complex is substantially soluble in methanol or chloroform and substantially insoluble in water. Said complex may be incorporated into phospholipid liposomes. Such platinum complexes encapsulated in phospholipid liposomes are useful for chemotherapy of platinum complex-sensitive tumors.

REFERENCES:
patent: 4284579 (1990-01-01), Meischen et al.
patent: 4906477 (1990-03-01), Kurono et al.
patent: 4913907 (1990-04-01), Jori et al.
patent: 4923854 (1990-05-01), Tilcock et al.
patent: 4946954 (1990-05-01), Talebian et al.
patent: 4956459 (1990-05-01), Talebian et al.
patent: 5059421 (1991-10-01), Saughrey et al.
patent: 5114928 (1992-05-01), Geijdos et al.
Khokhar et al., Inorganica Chimica Acta, 108:63-66 (1985).

Affiliated with

Also associated with

Rating

Hydrophobic cis-platinum complexes efficiently incorporated into does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydrophobic cis-platinum complexes efficiently incorporated into, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydrophobic cis-platinum complexes efficiently incorporated into will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2146923