Hydrophobic attachment site for adhesion peptides

Details Hydrophobic attachment site for adhesion peptides Hydrophobic attachment site for adhesion peptides

1992-08-20

1996-12-24

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

A61K 3800, C07K 500, C07K 700

Patent

active

055874568

ABSTRACT:
The invention provides a method of attaching peptides containing a biologically active site, for example RGD-containing adhesion peptides, to a solid surface through a hydrophobic domain, and peptides so attached. The hydrophobic domain can contain either hydrophobic amino acids, such as leucine, valine, isoleucine or phenylalanine, or fatty acids, such as, for example, myristic acid, palmitic acid, arachidic acid or other fatty acids. Additionally, spacers, such as amino acids, between the hydrophobic domain and the biologically active domain can improve the presentation of the biologically active site. Specific peptides of the invention include
GRGDSPASSKG.sub.4 RL.sub.6 RNH.sub.2 ;
GRGDSPASSKS.sub.3 RL.sub.6 RNH.sub.2 ; and
GRGDSPASSKSSKRL.sub.6 RNH.sub.2.

REFERENCES:
patent: 5120829 (1992-06-01), Pierschbacher

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