Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1986-12-31
1988-04-26
Lusignan, Michael R.
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204169, 427 35, 427 40, 427 451, 427164, B05D 306, B05D 506, C07C 324
Patent
active
047402822
ABSTRACT:
This invention relates to a process for the treatment of synthetic plastic, hydrophobic, transparent, intraocular lenses to avoid trauma which causes protein adhesion to occur on the surface of the lens thereby causing endothelial cell damage and corneal deterioration. The process includes the first step of cross-linking the surface of the synthetic plastic, hydrophobic, transparent, intraocular lens by treating the lens with a stream of gas containing from about 5-100% by weight hydrogen of a low pressure of about 0.5-5 Torr in the presence of an A.C. electrical discharge. The second step involves treating such cross-linked surface with hydroxyl radicals, thereby to hydrophilize the surface. The hydrogen may be pure or a component of an inert gas mixture, e.g. in helium. The hydroxyl radicals may be generated in a variety of ways, from low pressure water vapor by electric corona discharge, direct current discharge, alternating current discharge, microwave discharge, and radiofrequency discharge; from aqueous hydrogen peroxide by photolysis and radiolysis, or modified Fenton's reagent using Ti.sub.3+, V.sup.4+, Cr.sup.2+, or Fe.sup.2+ ions, or by electrolysis of oxygen to form aqueous hydrogen peroxide in the presence of the same ions. The product is a synthetic plastic, hydrophobic, transparent, intraocular lens having a permanently hydrophilized surface, which does not cause trauma in the eye when utilized as an intraocular lens following surgery. Previous intraocular lenses do not retain hydrophilicity, the surface reverting to hydrophobicity with time.
REFERENCES:
patent: 3183152 (1965-05-01), Szekely et al.
patent: 3925178 (1975-12-01), Gesser et al.
patent: 3940207 (1976-02-01), Barkdoll
patent: 3944347 (1976-03-01), Barkdoll
patent: 4170043 (1979-10-01), Knight et al.
patent: 4170661 (1979-10-01), Knight et al.
patent: 4409258 (1983-10-01), Feurer et al.
patent: 4445991 (1984-05-01), Arbit
patent: 4569858 (1986-02-01), Lim et al.
Schlick, S. et al., On the Apparent Reactions of Excited Inert-Gas Atoms with Organic Solids, The Journal of Chemical Physics, vol. 47, No. 5, 1875-1876, Sep. 1, 1967.
Hansen et al., Polymers Letters, vol. 4, pp. 203-209 (1966).
Hudis et al., J. Appl. Polym. Sci., vol. 19, pp. 451-459 (1975).
Sharma et al., J. Appl. Polym. Sci., vol. 26, pp. 2205-2210 (1981).
Gesser Hyman D.
Warriner Robert E.
LandOfFree
Hydrophilization of hydrophobic intraocular lenses does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hydrophilization of hydrophobic intraocular lenses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydrophilization of hydrophobic intraocular lenses will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-818197