Hydrophilic, swellable coatings for biosensors

Details Hydrophilic, swellable coatings for biosensors Hydrophilic, swellable coatings for biosensors

1996-10-24

1998-07-28

Cooney, Jr., John M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From reactant having at least one -n=c=x group as well as...

427 212, 427 58, 4284231, 528 85, C08G 1872, B05D 300

Patent

active

057864390

ABSTRACT:
Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.

REFERENCES:
patent: 5614586 (1997-03-01), Tang et al.
patent: 5674275 (1997-10-01), Tang et al.

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