Hydrophilic polyurethane gel foams, particularly for treating de

Details Hydrophilic polyurethane gel foams, particularly for treating de Hydrophilic polyurethane gel foams, particularly for treating de

1995-05-30

1998-12-01

Sergent, Rabon

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Cellular products or processes of preparing a cellular...

424445, 4283186, 4283193, 4284233, 521121, 521124, 521126, 521128, 521129, 521130, 521159, 521170, 521174, 523105, 523111, 602 46, 604304, 604307, 156 78, 156 79, 4272071, 4272084, 427373, 4273935, C08J 904, C08J 912, C08L 7504, A61F 1302, A61F 1315, A61L 1520, A61L 1526, A61L 1558

Patent

active

058440135

DESCRIPTION:

BRIEF SUMMARY
DESCRIPTION

Hydrophilic polyurethane gel foams, in particular for the treatment of deep wounds, wound dressings based on hydrophilic polyurethane gel foams and production processes
The present invention relates to polyurethane gel foams, in particular those for medical applications, and to processes for their production.
The present invention furthermore relates to polyurethane gel foams which absorb and bind aqueous liquids for medical applications, and to processes for their production.
The present invention also relates to polyurethane gel foams which are applied to carrier materials and absorb and bind aqueous liquids for medical applications, for example wound dressings such as wound plasters and adhesive plasters, and to processes for their production.
The polyurethane gel foams which, for example, absorb and bind aqueous liquids are also called "hydrogel foams" or "hydroactive gel foams" hereinafter. Instead of "polyurethane gel foams" it is also possible to use the terms "polyurethane foam gels" or "gel foams" and "foam gels".
Hydrogels are macromolecular, natural or synthetic substances which are able, because of a high content of hydrophilic groups, to bind water by absorption. The water-uptake capacity of many hydrogels is a multiple of the intrinsic weight of the anhydrous substance.
Hydrogels are used in a wide variety of forms in medicine. They are particularly suitable for wound management. They are able to protect wounds from drying out, to absorb wound discharge, to act as matrix for active substances of every type and to act as basis for colonization with autologous or heterologous skin cells.
Hydrogels can be used inter alia in the form of foams. Foams for managing cutaneous wounds or surgical wounds are known per se. Polyurethane foams or collagen foams are mainly used for this.
However, the prior art hydrogels have various disadvantages: soluble in water. This is usually unwanted because such products are not dimensionally stable. In addition, such products dissolve in an unwanted manner at the site of use and are then no longer available for the intended purpose.
Other products are distinguished by extensive polymer crosslinking. Although this avoids some of the disadvantages of the said class of substances, the swellability of these substances is substantially impaired or lost.
Self-adhesive gel foams are also known per se. Although these can in general be fixed very well to the skin, they usually have the disadvantage that their water-uptake capacity is greatly impaired.
Hydrophilic foams composed of polyurethane gels are furthermore known. PCT Application WO-88/01878 describes self-adhesive polyurethane foams or polyurethane foam gels which may, inter alia, contain methacrylates as copolymerized units. However, these foam gels are produced by addition of water.
Polyurethane gels based on a polyurethane matrix and high molecular weight polyols are described in EP-B-0 057 839. Self-adhesive sheet-like structures composed of polyurethane gels are disclosed in EP-B-0 147 588. The polyurethane gels disclosed in these last two publications are not foamed. The self-adhesive gels have isocyanate indices of 15 to 70 (EP 147 588).
It is evident from this that the OH functionality is always present in pronounced excess.
EP-B-57839, which relates not to self-adhesive medical adhesive plasters but to gel compositions or mould-making or pouring compositions containing active substances, has already mentioned the foaming of such compositions with air.
The Patent Application EP 0 453 286 describes superabsorbing foam compositions. The foaming is in this case achieved by the presence of water, where appropriate by additional low-boiling organic solvents.
EP 0 196 364 describes hydrophilic polyurethane foams which can be filled with water-absorbing polymers based on a copolymer of acrylic acid and potassium acetate and are intended for medical purposes. The polyurethane is produced on the basis of MDI. The poly-ether used has a minimum functionality of 2 hydroxyl groups, but preferably 2 to 3 hydro

REFERENCES:
patent: 4404296 (1983-09-01), Schapel
patent: 4466936 (1984-08-01), Schapel
patent: 4661099 (1987-04-01), von Bittera et al.
patent: 5160328 (1992-11-01), Cartmell et al.
patent: 5336695 (1994-08-01), Nass et al.
patent: 5362834 (1994-11-01), Schapel et al.

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