Hydrophilic polystyrene graft copolymer vehicle for intravaginal

Details Hydrophilic polystyrene graft copolymer vehicle for intravaginal Hydrophilic polystyrene graft copolymer vehicle for intravaginal

1996-11-12

1998-09-29

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424430, 514967, A61K 4732, A61K 902

Patent

active

058143297

ABSTRACT:
This invention pertains to the vaginal delivery of pharmacologically active agents and to polymeric formulations that allow for a prolonged release of the active agents in the vaginal environment. More specically the invention pertains to compositions for the delivery of drugs intravaginally comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group and at least one hydrophilic monomer having an ethylenically unsaturated functional group.

REFERENCES:
patent: 4085168 (1978-04-01), Milkovich et al.
patent: 4693887 (1987-09-01), Shah
patent: 5425955 (1995-06-01), Narayanan et al.
patent: 5429826 (1995-07-01), Nair et al.
patent: 5474768 (1995-12-01), Nair et al.
patent: 5536743 (1996-07-01), Borgman

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