Hydrophilic pharmaceutical composition containing ketoprofen lys

Details Hydrophilic pharmaceutical composition containing ketoprofen lys Hydrophilic pharmaceutical composition containing ketoprofen lys

1994-02-22

1997-03-25

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

514568, 514570, A61K 912

Patent

active

056141718

ABSTRACT:
A hydrophile pharmaceutical composition in the form of foam is described which contains as active ingredient Ketoprofen lysine salt having a concentration between 10 and 20% p/volume of solution which allows, for topic treatment, the maximum absorption of the active principle.
The foam is applied for the local treatment in painful and phlogistic conditions, of rheumatic or traumatic nature, of the articulations, of the musles, of the tendons and of the ligaments.

REFERENCES:
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patent: 4593044 (1986-06-01), Metz
patent: 4954332 (1990-09-01), Bissett et al.
WO-A-8 701 935, published Apr. 9, 1987.
Chemical Abstracts, vol. 114, No. 12, abstract No. 108976J.
Chemical Abstracts, vol. 104, No. 12, abstract No. 95462e.
Chemical Abstracts, vol. 110, No. 4, abstract No. 29115s.
Chemical Abstracts, vol. 109, No. 26, abstract No. 237046b.
Ca 109:237046b Nakagawa et al. Foam producing analgesic and anti inflammatory aerosols.
Abstract #CA99(24):200431x Pharmacokinetics of a Slow Release Preparation of Ketoprofen Lysine in Man Borsa et al.
Ketoprofen Penetration Into Suction Skin Blister Fluid: A Comparison of Two Topical Formulations of Ketoprofen Lysine; Advances in Therapy, vol. 10 No. 2 Mar./Apr. 1993; pp. 86-94.
Farmacocinetica di Ketoprofene Sale di Lisina Dopo Applicazione Percutanea Della Formulazione Schiuma: Risultati Sperimentali e Clinici; Faramci vol. 16 No. 9-10/'92; pp. 1-11.

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