Hydrophilic nonamine-containing and amine-containing copolymers

Details Hydrophilic nonamine-containing and amine-containing copolymers Hydrophilic nonamine-containing and amine-containing copolymers

1997-12-29

1999-07-27

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

526293, 5263031, 5263072, 5263078, 526310, 5263181, 526326, 526346, 514789, B01D 1500, B01J 3900

Patent

active

059291842

ABSTRACT:
The present invention relates to polymer compositions and methods of using said compositions for sequestering bile acids in a patient. The polymer compositions of this invention comprise a copolymer characterized by one or more hydrophilic nonamine-containing monomers or repeat units and one or more amine-containing monomers or repeat units. The amine-containing monomers or repeat units of the polymer compositions have one or more substituents bound to a portion of the amine nitrogens. The substituent or substituents which are bound to the amine nitrogens of the polymer composition can include a hydrophobic moiety and/or a quaternary amine-containing moiety. Suitable amine-containing monomers or repeat units include, but are not limited to, for example, vinylamine, allylamine, diallylamine, diallylmethylamine, and ethyleneimine, which are appropriately substituted, as described above.
The hydrophilic nonamine-containing monomer can be, but is not limited to, for example, allyl alcohol, vinyl alcohol, ethylene oxide, propylene oxide, hydroxyethylacrylate, hydroxyethylmethacrylate, hydroxypropylacrylate, hydroxypropylmethacrylate, poly(propyleneglycol) monomethacrylate, poly(ethyleneglycol) monomethacrylate, acrylic acid, carbon dioxide, and sulfur dioxide. Typically, the hydrophilic nonamine-containing monomer or repeat unit comprises from about 10 to about 90 mole percent of the polymer composition.

REFERENCES:
patent: 2874132 (1959-02-01), Riener
patent: 3288770 (1966-11-01), Butler
patent: 3308020 (1967-03-01), Wolf et al.
patent: 3383281 (1968-05-01), Wolf et al.
patent: 3562266 (1971-02-01), Minisci et al.
patent: 3692895 (1972-09-01), Nelson et al.
patent: 3780171 (1973-12-01), Irmscher et al.
patent: 3787474 (1974-01-01), Daniels et al.
patent: 3801641 (1974-04-01), Payot et al.
patent: 3803237 (1974-04-01), Lednicer et al.
patent: 3980770 (1976-09-01), Ingelman et al.
patent: 4027009 (1977-05-01), Grier et al.
patent: 4071478 (1978-01-01), Shen et al.
patent: 4098726 (1978-07-01), Wagner et al.
patent: 4101461 (1978-07-01), Strop et al.
patent: 4111859 (1978-09-01), Strop et al.
patent: 4205064 (1980-05-01), Wagner et al.
patent: 4217429 (1980-08-01), Wagner et al.
patent: 4340585 (1982-07-01), Borzatta et al.
patent: 4426489 (1984-01-01), Wessling et al.
patent: 4540760 (1985-09-01), Harada et al.
patent: 4557930 (1985-12-01), Kihara et al.
patent: 4559391 (1985-12-01), Ueda et al.
patent: 4605701 (1986-08-01), Harada et al.
patent: 4680360 (1987-07-01), Ueda et al.
patent: 4759923 (1988-07-01), Buntin et al.
patent: 5055197 (1991-10-01), Albright et al.
patent: 5142019 (1992-08-01), Sundararaman et al.
patent: 5189111 (1993-02-01), Danner
patent: 5236701 (1993-08-01), St. Pierre et al.
patent: 5300566 (1994-04-01), Pinschmidt, Jr. et al.
patent: 5374422 (1994-12-01), St. Pierre et al.
patent: 5395896 (1995-03-01), Moriya et al.
patent: 5414068 (1995-05-01), Bliem et al.
patent: 5428112 (1995-06-01), Ahlers et al.
patent: 5430110 (1995-07-01), Ahlers et al.
patent: 5451397 (1995-09-01), Albright et al.
patent: 5462730 (1995-10-01), McTaggart et al.
patent: 5500212 (1996-03-01), Bliem et al.
patent: 5624963 (1997-04-01), Mandeville, III et al.
Heming, A.E. and Flanagan, Thomas L., "Considerations in the Selection of Cation Exchange Resins for Therapeutic Use," Annals of the New York Academy of Sciences, 57:239-251 (1954).
McCarthy, Peter A., "New Approaches to Atherosclerosis: An Overview," Medicinal Research Reviews, 13(2):139-159 (1993).
Butler, G.B. and Do, C.H., "Comblike Cyclopolymers of Alkyldiallylamines and Alkyldiallylmethylammonium Chlorides," in Water-Soluble Polymers, eds. Shalaby, McCormick & Butler, Chapter 9, pp. 151-158 ACS Symposium Series 467 (1991).
Dubin, P.L. and Davis, D.D., "Quasi-Elastic Light Scattering of Polyelectrolyte-Micelle Complexes," Macromolecules 17: 1294-1296 (1984).
Wang, G.-J. and Engberts, J., "Fluorescence probing of the formation of hydrophobic microdomains by cross-linked poly(alkylmethyldiallylammonium bromides) in aqueous solution," Recl. Trav. Chim. Pays-Bas 113:390-393 (1994).
Kunitake, T., et al., "Catalyses of Polymer Complexes. 4. Polysoap-Catalyzed Decarboxylation of 6-Nitrobenzisoxazole-3-carboxylate Anion. Importance of the Hydrophobic Environment in Activation of the Anion," J. Org. Chem 42(2): 306-312 (1977).
Wang, G.-J. and Engberts, J., "Study of the Conformational State of Non-Cross-Linked and Cross-Linked Poly(alkylmethyldiallylammonium Chlorides) in Aqueous Solution by Fluorescence Probing," Gazzetta Chimica Italiana, 125: 393-397 (1995).
Kuron, G.W., et al., "The Bile Acid Binding and Hypocholesterolemic Action of Two Water-Soluble Polymers," Atherosclerosis, 37 353-360 (1980).
Harada, S. and Arai, K., "The Cyclo-copolymerization of Diallyl Compounds and Sulfur Dioxide," Die Makromolekulare Chemie 107: 64-93 (1967).
Wang, G.-J. and Engberts, J., "Induction of Aggregate Formation of Cationic Polysoaps and Surfactants by Low Concentrations of Additives in Aqueous Solution," Langmuir, 10(8): 2583-2587 (1994).
Wang, G.-J. and Engberts, J., "Synthesis of Hydrophobically and Electrostatically Modified Polyacrylamides and Their Catalytic Effects on the Unimolecular Decarboxylation of 6-Nitrobenzisoxazole-3-carboxylate Anion,"
Wang, G.-J. and Engberts, J., "Synthesis and Catalytic Properties of Non-Cross-Linked and Cross-Linked Poly(alkylmethyldiallylammonium bromides) Having Decyl, Octyl, and Hexyl Side Chains," J. Org. Chem, 60: 4030-4038 (1995).
Kevelam, J., et al., "Polymer-Surfactant Interactions Studied by Titration Microcalorimetry: Influence of Polymer Hydrophobicity, Electrostatic Forces, and Surfactant Aggregational State," Langmuir, 12(20): 4709-4717 (1996).
Wang, G.-J. and Engberts, J., "Synthesis and Catalytic Properties of Cross-Linked Hydrophobically Associating Poly(alkylmethyldiallylammonium bromides)," J. Org. Chem., 59(15): 4076-4081 (1994).
Yang, Y.J. and Engberts, J., "Synthesis and Catalytic Properties of Hydrophobically Modified Poly(alkylmethyldiallylammonium bromides)," J. Org. Chem., 56: 4300-4304 (1991).
Negi, Y., et al., "Cyclopolymerization of Diallylamine Derivatives in Dimethyl Sulfoxide," J. of Polymer Science: Part A-1, 5: 1951-1965 (1967).
Hodgkin, H. et al., "Use of .sup.13 C-NMR in the Study of Reactions on Crosslinked Resins," Published by John Wiley & Sons, J. of Polymer Science: Polymer Chemistry Edition, 19(5): 1239-1249 (1981).
Yeh, F., et al., "Nanoscale Supramolecular Structures in the Gels of Poly(Diallyldimethylammonium Chloride) Interacting with Sodium Dodecyl Sulfate," J. Am. Chem. Soc., 118(28): 6615-6618 (1996).
Boothe, J.E., et al., "Some Homo- and Copolymerization Studies of Dimethyldiallylammonium Chloride," J. Macromol. Sci.-Chem., A4(6): 1419-1430 (1970).
United States Serial No. 08/777,408, filed on Dec. 30, 1996, "Poly(diallylamine)-Based Bile Acid Sequestrant" by Stephen Randall Holmes-Farley.

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