Hydrophilic microparticles and methods to prepare same

Details Hydrophilic microparticles and methods to prepare same Hydrophilic microparticles and methods to prepare same

1997-10-02

2000-04-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424491, 424493, A61K 914

Patent

active

060485507

ABSTRACT:
The present invention comprises a material and a method of its preparation. The material may be described as hydrophilic microparticles, comprising a cluster of organic substance with a layer of polyelectrolyte on its surface. The present invention establishes an improved method for preparing aqueous colloidal dispersions of water-insoluble organic substances using polyionic hydrophilic polymers by which the stability of the suspension is maintained after removal of the stabilizing and/or solubilizing medium of the drug. This improved method can be utilized to formulate a variety of water-insoluble organic substances.

REFERENCES:
patent: 4963367 (1990-10-01), Ecanow
patent: 5286493 (1994-02-01), Oshlack et al.
patent: 5651991 (1997-07-01), Sugiyama et al.
patent: 5853698 (1998-12-01), Straub et al.

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