Hydrophilic, hydrophobic, and thermoreversible saccharide gels a

Details Hydrophilic, hydrophobic, and thermoreversible saccharide gels a Hydrophilic, hydrophobic, and thermoreversible saccharide gels a

1997-05-13

2000-01-25

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 172, 536 173, 536 179, 536 182, 536 185, 536 553, 536103, 5361231, 53612313, 424 11, 424456, 424461, 424466, C07H 1510, C07H 1504, C07H 1512

Patent

active

060180331

ABSTRACT:
Polymerizable saccharide monomers are made by the reaction of a saccharose and a (meth)acrylate. Hydrophilic, hydrophobic and thermoreversible gels and foams are formed upon polymerization of the saccharide monomers. Hydrophilic sucrose monomers are synthesized by reaction of sucrose with an epoxy acrylate. Hydrophobic sucrose monomers are synthesized by reaction of sucrose with methacrylol chloride followed by acetyl chloride. Thermoreversible sucrose monomers are obtained by modifying sucrose with polymerizable substituents prepared from methacryloyl chloride and aminocarboxylic acids. The modified sucrose monomers are copolymerized with hydrophobic poly(alkyleneoxide) (meth)acrylates to produce hydrogels exhibiting inverse thermoreversible properties. The thermosensitive hydrogels are biodegradable and can be used in the area of controlled drug delivery.

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