Hydrophilic free radicals for magnetic resonance imaging

Details Hydrophilic free radicals for magnetic resonance imaging Hydrophilic free radicals for magnetic resonance imaging

1992-04-30

1993-11-23

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

548518, 548542, 5483001, 514422, 514424, 514385, 436173, 1286534, G01N 2408, A61K 3140, A61K 31415

Patent

active

052642046

ABSTRACT:
Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance contrast media within the scope of the present invention include stable hydrophilic free radicals having a hydrophilic moiety, such as polyhydroxyalkyl groups and heterocyclic amino-alcohols such as dihydroxypyrrolidine, dihydroxypiperidine, and trihydroxypiperidine, and a stable free radical moiety, such as a nitroxide, phenoxy, or phenoxazinyl free radical moiety.

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patent: 4925652 (1990-05-01), Gries et al.
patent: 5104641 (1992-04-01), Rosen
Brasch, RC AJR 141:1019-1023 (1983).
W. R. Couet et al., "Factors Affecting Nitroxide Reduction in Ascorbate Solution and Tissue Homogenates", Magnetic Resonance Imaging, vol. 3, pp. 83-88, 1985.

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