Hydrophilic coatings with hydrating agents

Details Hydrophilic coatings with hydrating agents Hydrophilic coatings with hydrating agents

1996-10-10

1998-09-01

Buiz, Michael

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

604264, 604283, 604164, 604165, 604166, 604167, 604168, 604169, 623 11, 428 357, A61M 2500

Patent

active

058004122

ABSTRACT:
According to the invention, hydrating agents in ultrafine form may be incorporated in an organic coating solution with a uniform distribution that does not change due to settling. In preferred embodiments, the coating solution comprises salt dissolved in an appropriate organic solvent blend. In another embodiment, the hydrating agent may be in the form of ultrafine particles dispersed in the polymer solution. The dispersion may be obtained by adding a stream of the aqueous hydrating agent solution to the organic polymer solution in a controlled fashion, or salt particles may be formed in the polymer solution by acid-base neutralization in solution. The coating solutions are storage stable. When applied to a medical device, the coating solution produces a homogenous coating with desirable performance characteristics. The coatings of the invention adhere to the substrate but not to moist tissue with which they are placed in contact. The coatings of the invention provide indwelling devices with long-lasting lubricity after the device is inserted in a body.

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