Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2006-04-25
2006-04-25
Tate, Christopher R (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C514S002600, C514S054000, C514S056000, C514S057000, C530S410000, C525S054100, C525S054200, C536S021000, C536S054000, C536S084000
Reexamination Certificate
active
07034127
ABSTRACT:
Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer having a functional group capable of reacting with divinyl sulfone. Also disclosed are stable intermediates formed by partially reacting a hyaluronan with divinyl sulfone and stopping the reaction before completion to leave free, or reactive vinyl groups on the hyaluronan molecule available for conjugation with the biologically active substance.
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Larsen Nancy E.
Parent Edward G.
Cordero Garcia Marcela M
Fish & Richardson P.C.
Genzyme Corporation
Tate Christopher R
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