Hydrophilic assay reagent containing one member of specific bind

Details Hydrophilic assay reagent containing one member of specific bind Hydrophilic assay reagent containing one member of specific bind

1983-10-24

1987-12-15

Kepplinger, Esther M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

436518, 436531, 436532, 436534, 436808, 427 2, G01N 33546, G01N 33545, G01N 33543, G01N 33549

Patent

active

047133503

ABSTRACT:
This invention provides a hydrophilic specific binding assay reagent which is prepared by a process comprising the steps of reacting a partner of a specific binding pair and at least one hydrophilic substance with haloalkyl moieties associated with the surface of a solid phase and recovering the reagent so prepared from any unreacted binding partner. Preferably, the alpha-haloalkyl is chloromethyl and the at least one hydrophilic substance comprises at least one protein, such as albumin, and at least one non-proteinaceous amine to which the solid phase is impermeable, such as tris (hydroxymethyl) aminomethane. The specific binding assay reagent of the invention can be combined with other reagents to provide an assay composition.

REFERENCES:
patent: 4004979 (1977-01-01), Avrameas
patent: 4108976 (1978-08-01), Reese
patent: 4115540 (1978-09-01), Digenis
patent: 4210418 (1980-07-01), Brown
patent: 4220722 (1980-09-01), Rowley
patent: 4415700 (1983-11-01), Batz
patent: 4440903 (1984-04-01), Golstein
patent: 4547466 (1985-10-01), Turanchik et al.
patent: 4572901 (1986-02-01), Ceriani et al.

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