Hydronopol substituted benzimidazolone and quinazolinone...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C546S126000, C544S293000, C514S322000, C514S266220, C514S304000

Reexamination Certificate

active

07851630

ABSTRACT:
The invention relates to a group of hydronopol substituted benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel benzimidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved.The invention relates to compounds of the general formula (1)wherein the symbols have the meanings as given in the description.

REFERENCES:
patent: 2005/0070528 (2005-03-01), Den Hartog et al.
patent: 2005/0131004 (2005-06-01), Mentzel et al.
patent: 1069124 (2001-01-01), None
patent: 0 990 653 (2004-09-01), None
patent: 2 097 031 (1972-03-01), None
patent: WO 99/36421 (1999-07-01), None
patent: WO 01/39775 (2001-06-01), None
Zaveri et al., “Characterization of Opiates, Neuroleptics, and Synthetic Analogs at ORL1 and Opioid Receptors”:European Journal of Pharmacology, 428:29-36 (2001).
Derwent Abstract for FR 2 097 031.
International Search Report for PCT Application No. PCT/EP2004/052392.

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