Hydrolyzed sodium casein compositions for dialysis procedures

Details Hydrolyzed sodium casein compositions for dialysis procedures Hydrolyzed sodium casein compositions for dialysis procedures

1989-02-06

1990-03-06

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 8, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 530360, 530361, 530402, 530407, 530427, 530832, 530833, 435268, 435272, A61K 3718

Patent

active

049066161

ABSTRACT:
A medicinal composition, particularly but not exclusively for use in fluids for medical dialysis, contains, as an agent for maintaining the osmolality of the fluid, a protein hydrolysate resulting from the action of a proteolytic enzyme on the sodium caseinate fraction of milk protein. The enzyme is preferably trypsin but other proteolytic enzymes and enzyme mixtures may be used, examples being chymotrypsin, pancreatin and pronase.
The method of production involves treating the sodium caseinate in aqueous medium with the enzyme at the appropriate pH and temperature for optimum enzyme activity. The product of the enzymic hydrolysis, after filtration through a bacterial filter, adjustment of the osmolality to an appropriate level of around 300 mOsm/Kg and the pH to physiological level of about 6.6 and addition of physiological salt levels, constitutes the final product.

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