Hydrolytically unstable, biocompatible polymer

Details Hydrolytically unstable, biocompatible polymer Hydrolytically unstable, biocompatible polymer

1998-04-02

1999-10-05

Barts, Samuel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514533, 5147723, 5147724, 5147726, 514784, 514785, 526311, 528291, 528292, 424439, 424486, 424487, 424497, 560157, 560169, A61K 31215

Patent

active

059625201

ABSTRACT:
A hydrolytically unstable, biocompatible polymer capable of carrying and releasing a pharmaceutical compound when introduced into physiological media. In a preferred embodiment, the polymer contains ester linkages that are susceptible to hydrolytic degradation. A monomeric unit of the polymer can also be used as a hydrolytically unstable linking agent for quickening the degradation of polymers, particularly cross-linked polymers.

REFERENCES:
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patent: 5691423 (1997-11-01), Smith et al.
Polycondensation of .omega.-aminoalkylamino acid esters, Asahara, T.; Die Makro. Chemie, 136(3391), 211-219, 1970.
New nitric oxide-releasing zwitterions derived from polyamines, Hrabie et al., J. Org. Chem., 58(6), 1472-1476, 1993. Smith, et al., J. Med. Chem., 39:5, 1148-1155 1996.

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