Hydrolytically stable resins for use in anion-exchange chromatog

Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...

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210656, 2101982, B01D 1508

Patent

active

059252537

ABSTRACT:
In accordance with the present invention, an improved anion- exchange chromatographic composition has been formed which comprises synthetic resin support particles and anion exchange compounds attached thereto, wherein the anion-exchange compounds comprise an internal reactive group, which may be an ester, ketone or amide group, and a terminal quaternary ammonium salt which functions as an anion-exchange site. The compositions of the present invention exhibit improved hydrolytic stability as compared to other known anion-exchange chromatographic compositions due to the presence of linkers which increase the number of atoms separating the internal reactive group from the nitrogen atom of the terminal ammonium anion-exchange site. Formed articles and methods employing the anion-exchange chromatographic composition are also provided.

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