Hydrolytically labile microspheres of polysaccharide crosslinked

Details Hydrolytically labile microspheres of polysaccharide crosslinked Hydrolytically labile microspheres of polysaccharide crosslinked

1993-05-20

1996-08-27

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424445, 424499, A61L 1516

Patent

active

055499082

ABSTRACT:
A water swellable and hydrolytically labile (and therefore potentially biodegradable) non-toxic crosslinked polysaccharide in microsphere or bead form. The crosslinked polysaccharide comprises polysaccharide chains and crosslinking groups which are imidocarbonate groups, carbonate groups or a mixture thereof. The microspheres are predominantly in the range of about 1 micron to about 100 microns in diameter, preferably about 2-50 microns. The crosslinked polysaccharide polymer, which is preferably a crosslinked dextran, is formed by treating a water soluble non-crosslinked polysaccharide with a cyanogen halide (preferably cyanogen bromide) in an aqueous alkaline medium which is the disperse phase of a water-in-oil dispersion. The microspheres are useful in the treatment of wounds, in particular as an absorptive agent for wound exudates. The microspheres may be formed into a wound dressing which includes a blend of the microspheres and a hydrophobic adhesive matrix material on a waterproof backing sheet.

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Axen et al., European J. Biochem. 18 (1971) 351-360.
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