Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From phenol – phenol ether – or inorganic phenolate
Reexamination Certificate
2006-07-11
2006-07-11
Boykin, Terressa (Department: 1711)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
From phenol, phenol ether, or inorganic phenolate
C528S198000, C530S351000, C530S391900
Reexamination Certificate
active
07074878
ABSTRACT:
A water soluble polymer is provided having two or more oligomers linked to each other by hydrolytically degradable carbonate linkages. The polymer can be hydrolytically degraded into oligomers (e.g., oligomers of ethylene oxide) under physiological conditions. The polymer can be conjugated to biologically active agents such as proteins or peptides to impart improved water solubility, reduced immunogenicity, reduced rate of renal clearance, and increased stability. The polymer is useful in making hydrolytically degradable hydrogels which can be used in drug delivery and related biomedical applications. On example of the polymer is a poly (ether carbonate) of the formula X—O—[(—CH2CH2—O—)n—CO2—]n—(CH2CH2))n-y where X and Y are independently H, alkyl, alkenyl, aryl, or a reactive moiety, and at least one of X and Y is a reactive moiety.
REFERENCES:
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 5252714 (1993-10-01), Harris et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5463012 (1995-10-01), Ferruti et al.
patent: 5468478 (1995-11-01), Saifer et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5672662 (1997-09-01), Harris et al.
patent: 5824784 (1998-10-01), Kinstler et al.
patent: 5900461 (1999-05-01), Harris
patent: 5932462 (1999-08-01), Harris et al.
patent: WO 99/55760 (1999-11-01), None
Sawhney et al. “Biorodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly(α-hydroxy acid) Diacrylate Macromers,”Macromolecules, vol. 26, No. 4, pp. 581-587 (1993).
Verocese et al., “Surface Modification of Proteins—Activation of Monomethoxy-Polyethylene Glycols by Phenylchloroformates and Modification of Ribomuclease and Superoxide Dismutase,”Appl. Biochem. Biotech., vol. 11, pp. 141-152 (1985).
Sartore et al., “Enzyme Modification by MPEG with an Amino Acid or Peptide as Spacer Arms,”Appl. Biochem. Biotech., vol. 27, pp. 45-54 (1991).
Buckman et al., “Functionalization of Poly(ethylene glycol) and Monomethoxy-Poly(ethylene glycol),”Makromol. Chem.182, pp. 1379-1384 (1981).
Zalipsky et al., “Attachment of Drugs to Polyethylene Glycols,”Eur. Plym. J., vol. 19, No. 12, pp. 1177-1183 (1983).
Andresz et al., “Chemische Synthese verzweigter Polysaccharide,”Makromol. Chem., 179, pp. 301-312 (1978).
Olson et al., “Preparation and Characterization of Poly(ethylene glycol)ylated Human Growth Hormone Antagonist,”Poly(ethylene glycol)Chemistry and Biological Applications, pp. 170-181, Harris & Zalipsky Eds., ACS, Washington, DC (1997).
Abuchowski et al., “Cancer Therapy With Chemically Modified Enzymes. I. Antitumor Properties of Polyothylene Glycol-Asparaginase Conjugates,”Cancer Biochem. Biophys., vol. 7, pp. 175-186 (1984).
Joppich et al., “Peptides Flanked by Two Polymer Chains—Synthesis of Glycyl-L-tryptophylglycine Substituted by Poly(ethylene oxide) at both the Carboxy and the Amino End Groups,”Makromol. Chem., 180, pp. 1381-1384 (1979).
Pitha et al., “Detergents Linked to Polysaccharides: Preparation and Effects on Membranes and Cells,”Eur. J. Biochem., 94, pp. 11-18 (1979).
Elling et al., “Immunoaffinity Panitioning: Synthesis and Use of Polyerthylene Glycol-Oxirane for Coupling to Bovine Serum Albumia and Monoclonal Antibodies,”Biotech. Appl. Biochem., 13, pp. 354-362 (1991).
Beauchamp et al., “A New Procedure for the Synthesis of Polyethylene Glycol-Protein Adducts; Effects on Function, Receptor Recognition, and Clearance of Superoxide Dismutase, Lactoferrin, and Macroglobulin,”Anal. Biochem., 131, pp. 25-33 (1983).
Tondelli, et al., “Poly(Ethylene Glycol) Imidazolyl Formates as Oligomeric Drug-Binding Matrices,”J. Controlled Release, 1, pp. 251-257 (1985).
Harris et al., “Synthesis and Characterization of Poly(Ethylene Glycol) Derivatives,”J. Polym. Sci. Chem., vol. 22, pp. 341-352 (1984).
Goodson et al., “Site-Directed Pegylation of Recombinant Interleukin-2 at its Glycosylation Site,”Bio/Technology, vol. 8, pp. 343-346 (Apr., 1990).
Romani et al., “Synthesis of Unsymmetrical Cystine Peptides: Directed Disulfide Pairing With the Sulfenohydrazide Method.”Chemistry of Peptides and Proteins, vol. 2, pp. 29-34 (1984).
Kogan, “The Synthesis of Substituted Methoxy-Poly(Ethylene Glycol) Derivatives Suitable for Selective Protein Modification,”Synthetic Communications, 22(16), pp. 2417-2424 (1992).
Woghiren, et aL, “Protected Thiol-Polyethylene Glycol: A New Activated Polymer for Reversible Protein Modification,” Bioconj. Chem., vol. 4, No. 5, pp. 314-318 (1993).
Ouchi et al., “Design of Antitumor Agent-Terminated Poly(Ethylene Glycol) Conjugate as Macromolecular Prodrug,”Polymer Preprints, vol. 38, No. 1, pp. 582-583 (Apr., 1997).
Bentley Michael David
Harris J. Milton
Shen Xiaoming
Zhao Xuan
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