Hydrolytically degradable carbamate derivatives of poly...

Details Hydrolytically degradable carbamate derivatives of poly... Hydrolytically degradable carbamate derivatives of poly...

2006-04-28

2009-10-27

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

C424S078180, C424S078310

Reexamination Certificate

active

07608253

ABSTRACT:
Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.

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