Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active...
Reexamination Certificate
2011-08-02
2011-08-02
Peselev, Elli (Department: 1623)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
C424S078180, C424S078310
Reexamination Certificate
active
07988956
ABSTRACT:
Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.
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Bentley Michael D.
Zhao Xuan
Nektar Therapeutics
Peselev Elli
Wilson Mark A.
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