Hydrolytic enzyme inhibitors/inactivators and methods for using

Details Hydrolytic enzyme inhibitors/inactivators and methods for using Hydrolytic enzyme inhibitors/inactivators and methods for using

1991-06-10

1994-05-03

Higel, Floyd D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

435 18, 435195, 435238, 514120, 514126, 534727, 534852, 534861, 544 49, 544102, 558179, 558180, C12N 999, C12N 914, C12Q 134

Patent

active

053087666

ABSTRACT:
The present invention provides compounds that function as hydrolytic enzyme inhibitors (inactivators) and substrates. These compounds are useful in assays to detect and measure levels of hydrolytic enzyme activity and are more particularly useful in treatment regimens for various disease states and conditions implicating the underlying specific hydrolytic enzyme. Examples of hydrolytic enzymes include, but are not limited to, phospholipases, lipases, esterases, proteases, etc.

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Washburn, W. N., et al. J. Biol. Chem. 266:5042 (1991).
Reynolds, L. J. et al., Assay Strategies and Methods for Phospholipases In: Methods in Enzymology, vol. 197, ed. E. A. Dennis, publ. Harcourt, Brace, Jovanovich (1991).
Gaetjens, E., et al., J. Am. Chem. Soc. 82:5328 (1960).
Chang, J., et al., Biochem. Pharmacol. 36:2429 (1987).
Reynolds, L. J., J. Am. Chem. Soc. 110:5172 (1988).
Abeles, R. H. Chemical and Engineering News 61, 48 (1983).

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