Hydrogenation process for the formation of tetrahydro HMG-CoA re

Details Hydrogenation process for the formation of tetrahydro HMG-CoA re Hydrogenation process for the formation of tetrahydro HMG-CoA re

1987-09-03

1989-09-05

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549292, C07F 718, C07D30930

Patent

active

048640352

ABSTRACT:
A novel hydrogenation process, using a homogenous iridium or rhodium catalyst for the reduction of both double bonds of des-(.alpha.-methylbutyryl)-C-8-hydroxy lovastatin and C-8-amino, C-8-alkoxy and C-6-substituted analogs, is disclosed.

REFERENCES:
patent: 4351844 (1982-09-01), Patchett et al.
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 4584389 (1986-04-01), Sletzinger et al.
Evans et al., "Rhodium(I)-Catalyzed, etc", JACS 106 3866 (1984).
Crabtree et al., I, "Occurrence and Origin, etc", Organometallics, 2, 682 (1983).
Schruck et al., "Catalytic Hydrogenation, etc", CA 85:123066p (1976).
Crabtree et al., I, "Cationic Iridium, etc", CA 88:31361q (1978).
Santos et al., "Catalytic Activity and, etc", CA 100:180758t (1984).

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