Hydrogenation process for the formation of 4A,5-dihydro HMG-CoA

Details Hydrogenation process for the formation of 4A,5-dihydro HMG-CoA Hydrogenation process for the formation of 4A,5-dihydro HMG-CoA

1987-09-03

1989-10-24

Raymond,

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549292, C07D30930

Patent

active

048763640

ABSTRACT:
A novel hydrogenation process, employing an iridium or rhodium catalyst, in an alcoholic solvent mixture, for the reduction of the 4a,5 double bond in the polyhydronaphthyl ring of des-(.alpha.-methylbutyryl)-8-hydroxy-lovastatin or analogs thereof, is disclosed.

REFERENCES:
patent: 4490546 (1984-12-01), Kuo
Schrock et al, "Catalytic hydrogenation using, etc" CA 85:123066 D (1976).
Santos et al, "Catalytic activity and Visible, etc" CA 100:180758t (1984).
Crabtree et al I, "Cationic Iridiun dialefin, etc" CA 88:31361q (1978).
Kuo et al., J. Org. Chem., 48, 1991 (1983).
Evans et al., J. Am. Chem. Soc., 106, 3866 (1984).
Crabtree et al., Organometallics, 2, 682 (1983).

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