Hydrogenation process for the formation of 3,5-dihydro HMG-CoA r

Details Hydrogenation process for the formation of 3,5-dihydro HMG-CoA r Hydrogenation process for the formation of 3,5-dihydro HMG-CoA r

1987-09-03

1989-05-02

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549292, C07D30930, C07F 718

Patent

active

048269999

ABSTRACT:
A novel hydrogenation process, using a homogenous iridium or rhodium catalyst for selectively adding hydrogen to the 3,5 positions in the polyhydronaphthyl ring of lovastatin, simvastatin or C-8-acyl or C-6-substituted analogs thereof, is disclosed.

REFERENCES:
patent: 4351844 (1982-09-01), Patchett et al.
Kuo et al., "Reduction Transformation and, etc" JOC 48, 1991 (1983).
Schrach et al., "Catalytic Hydrogenation Using, etc" CA 85:123066p (1976).
Crabtree et al. I, "Cationic Iridium Diolefin, etc" CA 88:31361q (1978).
Crabtree et al. II, "Occurrence and Origin, etc" Organometallics 2 682 (1983).
Evans et al., "Rhodium(I)-Catalyzed, etc" JACS, 106, 3866 (1984).
Santos et al., "Catalytic Activity and Visible, "etc. CA 100:180758t (1984).

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