Hydrogenation of nitriles to produce amines

Details Hydrogenation of nitriles to produce amines Hydrogenation of nitriles to produce amines

1997-10-30

1999-02-09

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546243, 548550, 564 59, 564224, 564385, 564415, 564490, 564491, 564492, 564493, C07D22310, C07D21176, C07D20724, C07C27318, C07C23112, C07C20948

Patent

active

058696539

ABSTRACT:
An improved process for the catalytic hydrogenation of nitriles. The basic process comprises contacting the nitrile with hydrogen in the presence of a sponge or Raney cobalt catalyst under conditions for effecting conversion of the nitrile group to the primary amine. The improvement in the hydrogenation process resides in effecting the hydrogenation in the presence of a catalytic amount of lithium hydroxide and water. To achieve a catalytic amount of lithium hydroxide, the catalyst may be pretreated with the lithium hydroxide and/or the reaction may be carried out with the lithium hydroxide present in the reaction medium.

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patent: 5075507 (1991-12-01), Carr et al.
patent: 5254737 (1993-10-01), Zimmerman

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