Hydrogenation of aromatic-substituted olefins using organoruthen

Details Hydrogenation of aromatic-substituted olefins using organoruthen Hydrogenation of aromatic-substituted olefins using organoruthen

1991-05-13

1993-01-05

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560103, 560 52, 560 56, 560 55, 564180, 564182, 564300, 558388, C07C 6976

Patent

active

051772507

ABSTRACT:
A process is disclosed for the enantioselective hydrogenation of olefins of the formula ##STR1## where R is hydrogen or C.sub.1 to C.sub.6 linear or branched alkyl, Z is ##STR2## where R' is hydrogen or C.sub.1 to C.sub.6 linear or branched alkyl, --CN, C(NH)OR" where R" is C.sub.1 to C.sub.6 linear or branched alkyl, or --C(O)NH.sub.2 ; and Ar is phenyl or naphthyl unsubstituted or substituted with benzoyl or substituted benzoyl, C.sub.1 to C.sub.6 linear or branched alkyl, C.sub.1 to C.sub.6 linear or branched alkoxy, halo, or carboxylic acid or C.sub.1 to C.sub.6 linear or branched alkyl ester thereof, which comprises contacting said aromatic-substituted olefin with a catalytically effective amount of a ruthenium phosphite complex.

REFERENCES:
Ohkuma, T. et al., Tetrahedron Lett., 31(38) 5509-12 1990.
CA 110(26):233528h 1989.
Takaya, H. et al. JACS 109(5) 1596-7 1987.
Lubell, W. et al. Tetrahedron 2(7) 543-54 1991.

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