Hydrogenation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofu

Details Hydrogenation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofu Hydrogenation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofu

1992-04-30

1994-03-22

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 553, C07H 19167, A61K 3170

Patent

active

052965899

ABSTRACT:
A process for the preparation of 2-fluoro-9-beta-D-arabinofuranosyl purine (VII) by a reaction of palladium chloride and hydrochloric acid with 2-fluoro-9-(2,3,5-tribenzyl-beta-D-arabinofuranosyl)adenine (VI) at elevated pressures in a solvent for (VI) is described. The reaction is rapid, economical and efficient.

REFERENCES:
patent: Re29835 (1978-11-01), Witkowski et al.
patent: 4188378 (1980-02-01), Montgomery
patent: 5110919 (1992-05-01), Blumbergs et al.
Keller, F., et al., J. Org. Chem. 32, 1644-1646 (1967).
Imai et al., J. Org. Chem. 42: 2309-2313, 1977.
Montgomery et al., in J. Hetero. Chem. 16, 157 (1979).

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