Hydrogenation catalyst useful in the production of alpha-6-deoxy

Details Hydrogenation catalyst useful in the production of alpha-6-deoxy Hydrogenation catalyst useful in the production of alpha-6-deoxy

1989-11-29

1991-01-22

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556 19, 556 21, 556 26, C07F 1500

Patent

active

049872427

ABSTRACT:
A coordination compound useful as a hydrogenation catalyst, having the formula: ##STR1## wherein Ph is phenyl; R is hydrogen or C.sub.1 -C.sub.4 alkyl; and X is chloro, bromo or iodo. This compound is particularly useful as a homogeneous hydrogenation catalyst in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated.

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