Hydrogenated rapamycin derivatives

Details Hydrogenated rapamycin derivatives Hydrogenated rapamycin derivatives

1990-08-14

1991-06-11

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540456, 546 90, A61K 31395, C07D49116

Patent

active

050232622

ABSTRACT:
A derivative of rapamycin where one, two, or three of the double bonds at the 1-,3-, or 5-positions of rapamycin have been reduced to the corresponding alkane, or a pharmaceutically acceptable salt thereof, which by virtue of its antifungal activity is useful in treating fungal infections. ##STR1##

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patent: 4316885 (1982-02-01), Rakhit
patent: 4401653 (1983-04-01), Eng
patent: 4650803 (1987-03-01), Stella
patent: 4885171 (1989-12-01), Surendra
J. Antibiot. 28, 721-726 (1975).
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J. Antibiot. 31, 539-545 (1978).
Can. J. Physiol. Pharmacol. 55, 48 (1977).
FASEB 3, 3411 (1989).
FASEB 3, 5256 (1989).
Lancet, 1183, (1978).
Can. J. Chem. 58, 579 (1980).

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