Hydrogenated derivatives of antibiotic A/16686

Details Hydrogenated derivatives of antibiotic A/16686 Hydrogenated derivatives of antibiotic A/16686

1988-12-05

1992-04-28

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, A61K 3702, C07K 756

Patent

active

051089882

ABSTRACT:
The invention concerns tetrahydroderivatives of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686 and mixtures thereof. The tetrahydroderivatives are produced by hydrogenation of the above mentioned factors, preferably by catalytic hydrogenation.
The compounds have antibacterial activity, in particular, against widely diffused gram positive bacteria and are particularly useful for topical treatment of wound infections and acne.

REFERENCES:
patent: 4303646 (1981-12-01), Cavalleri et al.
patent: 4427656 (1984-01-01), Cavalleri et al.
B. Cavalleri et al., The Journal of Antibiotics, vol. XXXVII No. 4, pp. 309-317, (1984).

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