Hydrogen phosphonodithioate compositions

Details Hydrogen phosphonodithioate compositions Hydrogen phosphonodithioate compositions

1988-09-23

1993-03-16

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 267, 536 267, 536 2674, 536 268, C07H 19067, C07H 19073, C07H 19167, C07H 19173

Patent

active

051945991

ABSTRACT:
Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides. The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be therapeutically useful as antiviral and anticancer agents and may have other therapeutic or diagnostic uses. A method for making the hydrogen-phosphonodithioates is provided as well as a method for converting same to an activated intermediate for substitution on the phosphorus atom.

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