Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Compositions to be polymerized by wave energy wherein said...
Reexamination Certificate
2007-11-27
2007-11-27
Harlan, Robert D. (Department: 1713)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Compositions to be polymerized by wave energy wherein said...
C522S033000, C522S175000, C522S185000, C522S904000, C522S905000, C522S913000
Reexamination Certificate
active
11199613
ABSTRACT:
In one aspect, the present invention provides hydrogels comprising polymer molecules and bridging molecules, wherein substantially all the polymer molecules are cross-linked by hydrogen bonds between polymer molecules and bridging molecules, wherein each bridging molecule is linked to at least two polymer molecules, and wherein there are substantially no covalent linkages between the polymer molecules. In some embodiments, the polymer molecules are poly(vinyl alcohol) (PVA) and the bridging molecules are amino acids. Some embodiments of the invention provide devices comprising hydrogels, and pharmaceutical compositions comprising biologically active molecules within hydrogels. Another aspect provides methods for forming hydrogels of the invention.
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Kobayashi, M., et al., Preliminary Study of Polyvinyl Alcohol-Hydrogel (PVA-H) Artificial Meniscus,Biomaterials 24:639-647, 2003.
Lai, M.C., et al., “Chemical Stability of Peptides in Polymers. 1. Effect of Water on Peptide Deamindation in Poly(Vinyl Alcohol) and Poly(Vinyl Pyrrolidone) Matrixes,”J. Pharm. Sci. 88(10):1073-1080, Oct. 1999.
Li, J.K., et al., “Poly(Vinyl Alcohol) Nanoparticles Prepared by Freezing-Thawing Process for Protein/Peptide Drug Delivery,”J. Controlled Release 56:117-126, 1998.
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Mandal, T.K., and L.A. Bostanian, “Effect of Peptide Loading and Surfactant Concentration on the Characteristics of Physically Crosslinked Hydrogel,”Pharm. Dev. Tech. 5(4)555-560, 2000.
Mandal, T.K., et al., “Poly(d,1-Lactide-Co-Glycolide) Encapsulated Poly(Vinyl Alcohol) Hydrogel as a Drug Delivery System,”Pharm. Res. 19(11):1713-1719, Nov. 2002.
Sarti, B., and M. Scandola, “Viscoelastic and Thermal Properties of Collagen/Poly(Vinyl Alcohol) Blends,”Biomaterials 16(10):785-792, 1995.
Schmedlen, R.H., et al., “Photocrosslinkable Polyvinyl Alcohol Hydrogels That Can Be Modified With Cell Adhesion Peptides for Use in Tissue Engineering,”Biomaterials 23:4325-4332, 2002.
Stammen, J.A., “Mechanical Properties of a Novel PVA Hydroge in Shear and Unconfined Compression,”Biomaterials 22:799-806, 2001.
Suzuki, Y., et al., “A New Drug Delivery System With Controlled Release of Antibiotic Only in the Presence of Infection,”J. Biomed. Mat. Res. 42:112-116, 1998.
Takahashi, N., et al., “Effects of Cononsolvency on Gelation of Poly(Vinyl Alcohol) in Mixed Solvents of Dimethyl Sulfoxide and Water,”Polymer 44:4075-4078, 2003.
Xiao, C., and G. Zhou, “Synthesis and Properties of Degradable Poly(Vinyl Alcohol) Hydrogel,”Polymer Degradation and Stability 81:297-301, 2003.
Hassan, C.M., and N.A. Peppas, “Structure and Morphology of Freeze/Thawed PVA Hydrogels,” Macromolecules 33:2472-2479, 2000.
Kobayashi, M., et al., Preliminary Study of Polyvinyl Alcohol-Hydrogel (PVA H) Artifical Meniscus, Biomaterials 24:639-647, 2003.
Lai, M.C., et al., “Chemical Stability of Peptides in Polymers. 1. Effect of Water on Peptide Deamindation in Poly(Vinyl Alcohol) and Poly(Vinyl Pyrrolidone) Matrixes,” Journal of Pharmaceutical Sciences 88(10):1073-1080, Oct. 1999.
Li, J.K., et al. “Poly(Vinyl Alcohol) Nanoparticles Prepared by Freezing-Thawing Process for Protein/Peptide Drug Delivery,” Journal of Controlled Release 56:117-126, 1998.
Mallapragada, S.K., and N.A. Peppas, “Dissolution Mechanism of Semicrystalline Poly(Vinyl Alcohol) in Water,” Journal of Polymer Science: Part B: Polymer Physics 34:1339-1346, 1996.
Mandal, T.K., and L.A. Bostanian, “Effect of Peptide Loading and Surfactant Concentration on the Characteristics of Physically Crosslinked Hydrogel,” Pharmaceutical Development and Technology 5(4):555-560, 2000.
Mandal, T.K., et al., “Poly(d,1-Lactide-Co-Glycolide) Encapsulated Poly(Vinyl Alcohol) Hydrogel as a Drug Delivery System,” Pharmaceutical Research 19(11):1713-1719, Nov. 2002.
Sarti, B., and M. Scandola, “Viscoelastic and Thermal Properties of Collagen/Poly(Vinyl Alcohol) Blends,” Biomaterials 16(10):785-792, 1995.
Schmedlen, R.H., et al., “Photocrosslinkable Polyvinyl Alcohol Hydrogels That Can Be Modified With Cell Adhesion Peptides for Use in Tissue Engineering,” Biomaterials 23:4325-4332, 2002.
Stammen, J.A., “Mechanical Properties of a Novel PVA Hydroge in Shear and Unconfined Compression,” Biomaterials 22:799-806, 2001.
Suzuki, Y., et al., “A New Drug Delivery System With Controlled Release of Antibiotic Only in the Presence of Infection,” Journal of Biomedical Materials Research 42:112-116, 1998.
Takahashi, N., et al., “Effects of Cononsolvency on Gelation of Poly(Vinyl Alcohol) in Mixed Solvents of Dimethyl Sulfoxide and Water,” Polymer 44:4075-4078, 2003.
Xiao, C., and G. Zhou, “Synthesis and Properties of Degradable Poly(Vinyl Alcohol) Hydrogel,” Polymer Degradation and Stability 81:297-301, 2003.
Boeckl Maximiliane Silvia
Leber Elizabeth Reeves
Nair Prabha D.
Ratner Buddy D.
Christensen O'Connor Johnson & Kindness PLLC
Harlan Robert D.
University of Washington
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