Hydrogels formed by non-covalent linkages

Details Hydrogels formed by non-covalent linkages Hydrogels formed by non-covalent linkages

2005-09-27

2005-09-27

Harlan, Robert D. (Department: 1713)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Compositions to be polymerized by wave energy wherein said...

C522S033000, C522S175000, C522S183000, C522S904000, C522S905000, C522S913000

Reexamination Certificate

active

06949590

ABSTRACT:
In one aspect, the present invention provides hydrogels comprising polymer molecules and bridging molecules, wherein substantially all the polymer molecules are cross-linked by hydrogen bonds between polymer molecules and bridging molecules, wherein each bridging molecule is linked to at least two polymer molecules, and wherein there are substantially no covalent linkages between the polymer molecules. In some embodiments, the polymer molecules are poly(vinyl alcohol) (PVA) and the bridging molecules are amino acids. Some embodiments of the invention provide devices comprising hydrogels, and pharmaceutical compositions comprising biologically active molecules within hydrogels. Another aspect provides methods for forming hydrogels of the invention.

REFERENCES:
patent: 5541234 (1996-07-01), Unger et al.
patent: 6044201 (2000-03-01), Van Turnhout
Hassan, C.M., and N.A. Peppas, “Structure and Morphology of Freeze/Thawed PVA Hydrogels,”Macromolecules33:2472-2479, 2000.
Kobayashi, M., et al., Preliminary Study of Polyvinyl Alcohol-Hydrogel (PVA-H) Artificial Meniscus,Biomaterials24:639-647, 2003.
Lai, M.C., et al., “Chemical Stability of Peptides in Polymers. 1. Effect of Water on Peptide Deamindation in Poly(Vinyl Alcohol) and Poly(Vinyl Pyrrolidone) Matrixes,”Journal of Pharmaceutical Sciences88(10):1073-1080, Oct. 1999.
Li, J.K., et al., “Poly(Vinyl Alcohol) Nanoparticles Prepared by Freezing-Thawing Process for Protein/Peptide Drug Delivery,”Journal of Controlled Release56:117-126, 1998.
Mallaprasada, S.K., and N.A. Peppas, “Dissolution Mechanism of Semicrystalline Poly(Vinyl Alcohol) in Water,”Journal of Polymer Science: Part B: Polymer Physics34:1339-1346, 1996.
Mandal, T.K., and L.A. Bostanian, “Effect of Peptide Loading and Surfactant Concentration on the Characteristics of Physically Crosslinked Hydrogel,”Pharmaceutical Development and Technology5(4):555-560, 2000.
Mandal, T.K., et al., “Poly(d,1-Lactide-Co-Glycolide) Encapsulated Poly(Vinyl Alcohol) Hydrogel as a Drug Delivery System,”Pharmaceutical Research19(11):1713-1719, Nov. 2002.
Sarti, B., and M. Scandola, “Viscoelastic and Thermal Properties of Collagen/Poly(Vinyl Alcohol) Blends,”Biomaterials16(10):785-792, 1995.
Schmedlen, R.H., et al., “Photocrosslinkable Polyvinyl Alcohol Hydrogels That Can Be Modified With Cell Adhesion Peptides for Use in Tissue Engineering,”Biomaterials23:4325-4332, 2002.
Stammen, J.A., “Mechanical Properties of a Novel PVA Hydroge in Shear and Unconfined Compression,”Biomaterials22:799-806, 2001.
Suzuki, Y., et al., “A New Drug Delivery System With Controlled Release of Antibiotic Only in the Presence of Infection,”Journal of Biomedical Materials Research42:112-116, 1998.
Takahashi, N., et al., “Effects of Cononsolvency on Gelation of Poly(Vinyl Alcohol) in Mixed Solvents of Dimethyl Sulfoxide and Water,”Polymer44:4075-4078, 2003.
Xiao, C., and G. Zhou, “Synthesis and Properties of Degradable Poly(Vinyl Alcohol)Hydrogel,”Polymer Degradation and Stability81:297-301, 2003.

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