Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1993-11-04
1996-06-25
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4241891, 4242151, 4242121, 4242191, 4242171, 4242381, 4242101, 4242091, 4242491, 424468, 424 7801, 424489, 424499, A61K 3900, A61K 3938, A61K 950, A61K 914
Patent
active
055297773
ABSTRACT:
Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen, and, optionally, the polymer is crosslinked to form a stable microparticle. Preferred polymers are alginate and polyphosphazenes, and mixtures thereof. Microparticles can be adminstered parenterally or mucosally. For oral delivery, the microparticles are preferably fifteen microns or less in diameter, and adhere to the mucosal lining of the gastrointestinal tract, increasing uptake by the reticuloendothelium.
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Andrianov Alexander K.
Jenkins Sharon A.
Payne Lendon G.
Roberts Bryan E.
Ferraro Gregory D.
Housel James C.
Lillie Raymond J.
Minnifield N. M.
Olstein Elliot M.
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