Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2002-11-18
2009-08-04
Saucier, Sandra (Department: 1651)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
Reexamination Certificate
active
07569222
ABSTRACT:
The invention disclosed is a hydrogel composition for use as dural substitute, for wound closure of cleft palate and regeneration, and as substrate for cell delivery to the eye. The hydrogel is made of a copolymer of (a) an N-substituted (meth)acrylamide, and (b) a hydroxyalkyl (meth)acrylate, which is covalently crosslinked with dimethacrylate monomers. The swollen gel is in the form of a sheet or membrane that is readily sterilisable, being homogeneous or heterogeneous, non-degradable, non resorbable, elastically deformable, and has an equilibrium water content of at least 50%.
REFERENCES:
patent: 4400833 (1983-08-01), Kurland
patent: 5266325 (1993-11-01), Kuzma et al.
patent: 5861034 (1999-01-01), Taira et al.
patent: 5863551 (1999-01-01), Woerly
patent: 5997895 (1999-12-01), Narotam et al.
CAS abstract of Vetvicka et al. CS 223295, obtained on Sep. 12, 2006 on CAPlus/STN, 2 pages.
Taber's Cyclopedic medical Dictionary (1985) 15th ediction. Thomas, C. editor (F.A. Davis Company: Philadelphia, PA), pp. 474-475.
Park et al. “Thermoreversible gel containing RGD sequence as a extracellular matrix” Proceedings of the International Symposium on Controlled Release of Bioactive Materials (2000), 27th, 249-250; CAS abstract only. Downloaded from the CAPLUS database on Jul. 15, 2007.
Lukas et al. “Hydrogels for encapsulation of mammalian cells” Macromol. Symp. (Aug. 2001) 172: 157-165.
Friends et al. “Hydrogels Based on Copolymers of N-(2-hydroxyethyl)methacrylamide, 2-Hydroxyethylmethacrylate and 4-t-buttyl-2-hydroxycyclohexyl methacrylate” J. Polymer Sci. (1993) 49: 1869-1876.
McCulley et al., Corneal Endothelial Transplantation, Ophthalmology, Mar. 1980, vol. 87, No. 3, pp. 194-201.
Bhatia et al., A synthetic dural prosthesis constructed from hydroxyethylmethacrylate hydrogels, J Neurosurg, 1995; 83: 897-902.
Harat et al., Experimental evaluation of the net “Dalop” covered with collagen as the dural substitute, Zent. bl. Neurochir., 1989, 50: 145-148.
Laquerriere et al., Experimental evaluation of bilayered human collagen as a dural substitute, J. Neurosurg., 1993, 78(3): 487-491.
Maurer et al., Vicryl (polyglactin 910) mesh as a dural substitute, J. Neurosurg., 1985, 63(3): 448-452.
Meddings et al., Collagen vicryl—a new dural prosthesis, Acta Neurochir., 1992, 117(1-2): 53-58.
Pietrucha, K., New collagen implant as dural substitute, Biomaterials, 1991, 12: 320-323.
Sakas et al., Biologically inert synthetic dural substitutes, Appraisal of a medical-grade aliphatic polyurethane and a polysiloxane-carbonate block copolymer, J. Neurosurg., 1990, 73(6): 936-941.
San-Galli et al., Use of a biodegradable elastin-fibrin material, Neuroplast, as a dural substitute, Biomaterials, 1996, 17(11): 1081-1085.
Thompson et al., Silastic dural substitute: experience of its use in spinal and foramen magnum surgery, Br. J. Neurosurg., 1994, 8(2): 157-167.
Yamada et al., Development of a dural substitute from synthetic bioabsorbable polymers, J. Neurosurg., 1997, 86(6): 1012-1017.
Yamagata et al., Clinical experience with expanded polytetrafluoroethylene sheet used as an artificial dura mater, Neurol Med Chir., 1993, 33(8): 582-585.
Bhatt et al., Experimental transplantation of human retinal pigment epithelial cells on collagen substrates., Am. J. Ophthalmol., 1994, 117: 214-221.
Hadlock et al., Ocular cell monolayers cultured on biodegradable substrates, Tissue Eng., 1999, 5: 187-196.
Hartmann et al., Human and porcine anterior lens capsule as support for growing and grafting retinal pigment epithelium and iris pigment epithelium, Graefe3 s Arch Clin Exp Ophthalmol., 1999, 237: 940-945.
Huang et al., Preparation and transplantation of photoreceptor sheets, Current Eye Res., 1998, 17: 573-585.
Lu et al., Retinal pigment epithelial cell adhesion on novel micropatterned surfaces fabricated from synthetic biodegradable polymers, Biomaterials, 2001, 22: 291-297.
Lu et al., Retinal pigment epithelium cell culture on thin biodegradable poly(DL-lactic-co-glycolic acid) films, J Biomater Sci Polymer Ed, 1998, 9: 1187-1205.
Mohay et al., Transplantation of corneal endothelial cells using a cell carrier device, Cornea 1994, 13(2): 173-182.
Nakamura, T. et al., Tumorigenicity of poly-L-lactide (PLLA) plates compared with medical-grade polyethylene, J Biomed mater res., 1994, 28: 17-25.
Oganesian et al., A new model of retinal pigment epithelium transplantation with microspheres, Arch Ophthalmol, 1999, 117: 1192-1200.
Pistner et al., Poly(L-lactide): a long-term degradation study in vivo, Biomat., 1993, 14: 671-677.
Tezel et al., Fate of human retinal pigment epithelial cells seeded onto layers of human Bruch's membrane, Inv. Ophthalmol. & Visual Sci., 1999, 40(2): 467-476.
O'Neill et al., Use of a porcine dermis as a dural substitute in 72 patients, J. Neurosurg., 1984, 61: 351-354.
Gudmundsson et a., Complications to the use of Vicryl-Collagen Dural Substitute, Acta Neurochir, 1995, 132 : 145-147.
Keller et al., Repair of spinal dural defects with vicryl (polyglactin 910) mesh, Journal of spinal disorders, 1989, 2 (2) : 87-92.
Cohen et al., Inflammatory reaction to synthetic dural substitute, J. Neurosurg. 1989, 70 : 633-635.
Buchanan & Ingersoll & Rooney PC
Hanley Susan
Saucier Sandra
LandOfFree
Hydrogel membrane composition and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hydrogel membrane composition and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydrogel membrane composition and use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4056627